Analysis performed on 2024-09-30 10:20:00
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 18095 | 145 | 17950 | 11303 |
| Archaea | 1091 | 22 | 1069 | 463 |
| Vertebrata | 803 | 199 | 604 | 434 |
| Mammals | 289 | 50 | 239 | 125 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 501 | 23 | 425 |
| Domains | |
|---|---|
| Current Study | 1, 45 |
| Guo et al (2010) | 6, 24 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 457 | 44 | 501 | 10.386364 |
| Number of Variants | 402 | 46 | 448 | 8.739130 |
| Number of Pathogenic Variants | 22 | 1 | 23 | 22.000000 |
| Number of Benign/Unknown Variants | 380 | 45 | 425 | 8.444444 |
| Fisher exact test | 0.494323 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 482 | 19 | 501 | 25.368421 |
| Number of Variants | 426 | 22 | 448 | 19.363636 |
| Number of Pathogenic Variants | 23 | 0 | 23 | Undefined |
| Number of Benign/Unknown Variants | 403 | 22 | 425 | 18.318182 |
| Fisher exact test | 0.61834 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 457 | 44 | 0.95 (0.00) | 0.76 (0.02) | 9.914e-01 | 7.817e-01 | 17973.00 | 2.21e-18 |
| Guo et al (2010) | 482 | 19 | 0.94 (0.00) | 0.70 (0.04) | 9.912e-01 | 7.049e-01 | 8416.00 | 2.44e-10 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.